Do Cannabis-Infused Suppositories Actually Work?

CBD suppositories can remedy menstrual cramps and hemorrhoids. And we all know how that goes, laying in bed, with your knees to your chest, and a heating pad on your stomach. But what if I told you all of that could be completely eliminated with one thing? Well look no further, because it can! Just like with the hemorrhoids, the CBD stops the absorption of anandamide, but it also helps the uterine muscles relax. Which is essentially what menstrual cramps are. If you suffer from horrid period pains, these just might be your saving grace.

Why CBD Suppositories Are An Effective Way to Take CBD

When you take a suppository, the drug is immediately in a moist environment against a permeable membrane. The reason the moisture is important is that it allows the dosage form (suppository) to begin dissolving immediately. Additionally, most drugs can not be absorbed until they are in an aqueous solution (this is why liquid medicines work faster than tablets.)

Naturally the stomach is also very moist, but even though the dosage form (tablet or capsule) begins dissolving immediately it can’t be absorbed in the stomach. The stomach is lined with a layer of mucus that works to protect the stomach lining from the acid and digestive enzymes found in the stomach. While some of the drug can pass through the mucus layer, the rate of drug absorption across the mucus lining is so slow it doesn’t really matter.

In short, as soon as you insert a suppository it starts being absorbed, while oral dosage forms have to wait until it is moved into the small intestine.